| NUKLEONIKA 2006, 51(Supplement 1):s121-s128
INFLUENCE OF RADIATION STERILIZATION
ON POLY(ESTER URETHANES) DESIGNED
FOR MEDICAL APPLICATIONS
Grażyna Przybytniak1, Ewa Kornacka1, Joanna Ryszkowska2, Monika Bil2,
Andrzej Rafalski1, Piotr Woźniak3, Małgorzata Lewandowska-Szumieł3
1 Institute of Nuclear Chemistry and Technology, 16 Dorodna Str., 03-195 Warszawa, Poland
2 Faculty of Materials Science and Engineering, Warsaw University of Technology,
141 Wołoska Str., 02-507 Warszawa, Poland
3 Department of Biophysics and Human Physiology, Medical University of Warsaw,
5 Chałubińskiego Str., 01-004 Warszawa, Poland
Preparation of scaffolds for tissue regeneration requires elucidation of chemical and physical
processes induced by ionizing radiation during radiation sterilization of polymeric materials
used for these purposes. Such treatment induces many unintended and desired reactions that
lead either to degradation or cross-linking of macromolecules. It was found that in
poly(ester urethane) the ester segments are responsible predominantly for radiation induced
phenomena. Some radicals generated following irradiation were identified under cryogenic conditions.
Upon exposure to sterilizing dose cross-linking was confirmed on the basis of rheological changes
in melted polymers. The results obtained by EPR spectroscopy and DRS revealed a relatively high
susceptibility of poly(ester urethanes) on oxidation.
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