NUKLEONIKA 2009, 54(2):135-141

PREPARATION AND BIOLOGICAL EVALUATION OF [⁶¹Cu]BLEOMYCIN COMPLEX AS A POSSIBLE PET RADIOPHARMACEUTICAL
IN NORMAL AND FIBROSARCOMA-BEARING ANIMALS

Amir R. Jalilian¹, Hassan Zandi², Daryoush Sardari², Mehdi Akhlaghi¹,
Mohsen Kamali-Dehghan¹, Kamaleddin Shafaei¹, Abbas Majdabadi¹

¹ Agricultural, Medical and Industrial Research School (AMIRS-NSTRI),
Karaj, P. O. Box 31485-498, Iran
² Science and Research Unit, Islamic Azad University,
P. O. Box 14155-775, Postal code: 1477893855, Tehran, Iran

[⁶¹Cu]bleomycin ([⁶¹Cu]BLM) was prepared using [⁶¹Cu]CuCl₂ produced via ^natZn(p,x)⁶¹Cu. [⁶¹Cu]BLM was prepared under optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 92.5–370 MBq ⁶¹CuCl₂) with radiochemical purity over 98% shown by HPLC and RTLC. [⁶¹Cu]BLM was administered into normal and tumor bearing rodents up to 210 min followed by biodistribution and co-incidence imaging studies. A significant tumor/non tumor accumulation was observed either by animal sacrification or an imaging method. [⁶¹Cu]BLM can be a potential PET radiotracer for tumor imaging.

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PREPARATION AND BIOLOGICAL EVALUATION OF [61Cu]BLEOMYCIN COMPLEX AS A POSSIBLE PET RADIOPHARMACEUTICAL IN NORMAL AND FIBROSARCOMA-BEARING ANIMALS

PREPARATION AND BIOLOGICAL EVALUATION OF [⁶¹Cu]BLEOMYCIN COMPLEX AS A POSSIBLE PET RADIOPHARMACEUTICAL
IN NORMAL AND FIBROSARCOMA-BEARING ANIMALS