NUKLEONIKA 2011, 56(1):35-40

 


PREPARATION AND EVALUATION OF A [66Ga]GALLIUM CHITOSAN COMPLEX IN FIBROSARCOMA BEARING ANIMAL MODELS



Ali Pourjavadi1, Mehdi Akhlaghi1, Amir R. Jalilian2

1 Polymer Research Laboratory, Department of Chemistry,
Sharif University of Technology, P. O. Box 11365-9516, Tehran, Iran
2 Radiopharmaceutical Research and Development Laboratory (RRDL),
Nuclear Science and Technology Research Institute (NSTRI),
Postal code: 14155-1339, Tehran, Iran

[66Ga]gallium chitosan complex was prepared with a high radiochemical purity (> 99%) in dilute acetic acid solution. The radiochemical purity of [66Ga]gallium chitosan complex was checked by using paper chromatography technique. The prepared complex solution was injected intratumoral to fibrosarcoma-bearing mice and the leakage of radioactivity from injection site was investigated. Approximately, 85.4% of the injected dose was retained in the injection site 54 h after injection and most of the leaked radioactivity was accumulated in the blood, liver (0.5%) and lung (6.5%).

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