NUKLEONIKA 2012, 57(3):389-399

 


MAJOR, MINOR, AND TRACE ELEMENTS IN WHOLE BLOOD
OF PATIENTS WITH DIFFERENT LEUKEMIA PATTERNS



Ali Khuder1, Mohammed A. Bakir2, Amin Solaiman3, Haisam Issa1, Khozama Habil2,
Ali Mohammad2

1 Department of Chemistry, Atomic Energy Commission,
P. O. Box 6091, Damascus, Syria

2 Department of Radiation Medicine, Atomic Energy Commission, P. O. Box 6091, Damascus, Syria
3 Al-Mouasat Hospital, Damascus, Syria


The elemental sensitivity method for X-ray fluorescence analysis was applied to determine S, Cl, K, Ca, Fe, Cu, Zn, Br, and Rb in the whole blood of leukemia patients and healthy volunteers. Leukemia samples were classified according to type, growth, and age of participants. Studentís t-test results showed that, the mean concentration of the studied elements was significantly lower in leukemia patients than that in controls. Strong mutual correlations (r > 0.50) in the whole blood of leukemia patients were observed between S-Ca, K-Fe, K-Ca, Fe-Zn, K-Zn, K-Rb, Fe-Rb, Zn-Rb, S-Cl, S-K, Ca-Fe, Cl-Ca, and Ca-Rb; whereas, S-K, S-Ca, S-Cl, Cl-K, Cl-Ca, Fe-Zn, Zn-Rb, Fe-Rb, K-Fe, and Zn-Br exhibited strong relationships (r > 0.50) in the whole blood of controls, all were significant at p < 0.05. Significant differences between grouping of studied elements in the control group and all classified leukemia groups, except younger age-group, were obtained using principal component analysis. The study indicated appreciably different patterns of element distribution and mutual relationships in the whole blood of leukemia patients in comparison with controls.


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