| NUKLEONIKA 2013, 58(3):401-405
EPR STUDIES OF CLADOSPORIUM CLADOSPORIOIDES COMPLEXES
WITH AMPHOTERICIN B
Magdalena Zdybel1, Barbara Pilawa1, Ewa Buszman2, Teresa Witoszyńska2
1 Department of Biophysics,
School of Pharmacy with the Division of Laboratory Medicine,
Medical University of Silesia in Katowice,
8 Jedności Str., 41-200 Sosnowiec, Poland
2 Department of Pharmaceutical Chemistry,
School of Pharmacy with the Division of Laboratory Medicine,
Medical University of Silesia in Katowice,
4 Jagiellońska Str., 41-200 Sosnowiec, Poland
Free radicals in Cladosporium cladosporioides cultured with amphotericin B were spectroscopically studied. The effect of drug concentrations on free radicals in the fungal melanin biopolymer was examined. It was pointed out that the concentrations of free radicals in the complexes of Cladosporium cladosporioides mycelium with amphotericin B depend on the drug concentrations. Eumelanin dominates in the fungal studied samples. The slow spin-lattice relaxation processes exist in the tested samples. Free radicals take a part in the formation of Cladosporium cladosporioides mycelium complexes with amphotericin B.
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