| NUKLEONIKA 2013, 58(3):407-411
EFFECT OF MICROWAVE POWER ON EPR SPECTRA
OF DOPA-MELANIN-NETILMICIN COMPLEXES WITH DIFFERENT DRUG CONCENTRATION - A STUDY AT TEMPERATURES IN THE RANGE OF 125-275 K
Magdalena Zdybel1, Barbara Pilawa1, Ewa Buszman2, Dorota Wrześniok2,
Ryszard Krzyminiewski3, Zdzisław Kruczyński3
1 Department of Biophysics,
School of Pharmacy with the Division of Laboratory Medicine,
Medical University of Silesia in Katowice,
8 Jedności Str., 41-200 Sosnowiec, Poland
2 Department of Pharmaceutical Chemistry,
School of Pharmacy with the Division of Laboratory Medicine,
Medical University of Silesia in Katowice,
4 Jagiellońska Str., 41-200 Sosnowiec, Poland
3 Department of Medical Physics, Institute of Physics,
Adam Mickiewicz University, 85 Umultowska Str., 61-614 Poznań, Poland
Electron paramagnetic resonance (EPR) spectra of the model eumelanin – DOPA-melanin complexes with netilmicin measured with a microwave power in the range 0.3–200 mW were examined. The influence of microwave power on amplitudes (A) and linewidths (#DELTA#Bpp) of the spectra was determined. The EPR spectra were recorded by a BRUKER spectrometer at temperatures 125, 175, 225 and 275 K. Continuous microwave saturation of EPR lines was used to compare the acceleration of spin-lattice relaxation processes in melanin samples. Changes of the parameters of the EPR spectra of DOPA-melanin-netilmicin complexes, with the microwave power for the samples differing in netilmicin concentrations, were observed. The effect of temperature on the changes of the EPR spectra of the analyzed melanin complexes with the microwave power was determined. The spin-lattice relaxation is faster at higher temperatures for all the tested melanin complexes.
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